The drug is excreted principally while in the urine, largely as inactive metabolites and little amounts of free of charge and conjugated morphine. Negligible quantities of codeine and its metabolites are located in the feces.
Disposal of Unused Promethazine HCl and Codeine Phosphate Oral Answer Advise patients to effectively get rid of unused Promethazine HCl and Codeine Phosphate Oral Answer. Recommend people to toss the drug during the domestic trash next these techniques. one) Take away them from their first containers and mix them with an undesirable substance, like utilized coffee grounds or kitty litter (this can make the drug significantly less desirable to youngsters and pets, and unrecognizable to people that could deliberately go throughout the trash trying to get drugs).
Energetic and prophylactic procedure of movement sickness. Antiemetic therapy in postoperative people.
Concomitant administration of promethazine goods with other respiratory depressants has an association with respiratory despair, and often death, in pediatric clients.
Particular scientific studies to test the motion with the drug on parturition, lactation, and development of your animal neonate weren't performed, but a general preliminary review in rats indicated no impact on these parameters.
Codeine is understood to become significantly excreted from the kidney, and the potential risk of adverse reactions to this drug could be bigger in sufferers with impaired renal functionality.
Promethazine HCl and Codeine Phosphate Oral Option must be utilized with warning in people with bone- marrow depression. Leukopenia and agranulocytosis are actually noted, commonly when promethazine has actually been used in Affiliation with other identified marrow-toxic brokers.
Suggest people to constantly use an exact milliliter measuring unit when measuring and administering Promethazine HCl and Codeine Phosphate Oral Alternative. Tell people that a home teaspoon is not really an correct measuring product and these types of use could lead to overdosage and major adverse reactions [see Overdosage (10)].
are pregnant or prepare to be pregnant. Promethazine Hydrochloride and Codeine Phosphate Oral Answer can hurt your unborn toddler. See “What on earth is A very powerful information and facts I ought to know about Promethazine Hydrochloride and Codeine Phosphate Oral Alternative?” are breastfeeding or want to breastfeed. Codeine passes into your breast milk and could potentially cause really serious Uncomfortable side effects with your infant such as enhanced sleepiness, respiration difficulties (respiratory despair), and Demise. It isn't known if promethazine can pass into your breast milk.
Promethazine HCl happens as being a white to faint yellow, practically odorless, crystalline powder which slowly and gradually oxidizes and turns blue on prolonged publicity to air. It really is freely soluble in drinking water and soluble in alcohol.
Thing to consider really should be offered towards the discontinuation of promethazine HCl and to the usage of other medicine if these reactions occur. Respiratory depression, nightmares, delirium, and agitated conduct have also been claimed in Many of these sufferers.
The diagnostic analysis of patients using this type of syndrome is intricate. In arriving in a analysis, it more info is necessary to establish scenarios where the medical presentation incorporates both equally major health care health issues (e.
Greater stress with your head (enhanced intracranial strain). Avoid using Promethazine Hydrochloride and Codeine Phosphate Oral Solution In case you have a head harm or have already been advised that you've alterations inside the tissue of your Mind (Mind lesions) or amplified force as part of your head.
Promethazine is metabolized through the liver to a range of inactive metabolites for instance sulfoxides of promethazine, N-demethylpromethazine and various glucuronides.